Surgical Stress, glucocorticoids, cancer, and antidepressants
There is evidence that operative stress may result in decreased resistance of the host to cancer metastasis and that this effect is mediated by stress induced hypersecretion of glucocorticoids.
Garabal M. Nunez M, Pereiro D, Riveriro P, Losada C, Fernandez-Rial J, et al. Effects of fluoxetine on the development of lung metastases induced by operative stress in rats. Life Sci 1998;63:31-8. Pg. 141